Bio-Gide

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	Bio-Gide®
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	Bio-Oss Collagen®

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	Implantology
		Sinus Floor Augmentation
	Periodontology
	Ridge Preservation

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Bio-Gide^®Resorbable Bilayer Membrane

Bio-Gide® consists of highly purified collagen types I and III (porcine origin). The membrane is highly biocompatible and supports wound healing. The three-dimensional, natural fiber structure promotes cell adhesion, serves as a matrix for soft tissue support and provides a barrier to the ingrowth of overlying soft tissue into underlying bony defects.

Experience shows there is low risk of postoperative membrane exposure. Should wound dehiscence occur, soft tissue healing and closure of the dehiscence defect usually follows.

The barrier function of Bio-Gide® lasts for several months prohibiting soft tissue ingrowth into the bony defect facilitating undisturbed bone regeneration. Resorption takes place enzymatically and without irritation.

The native collagen fibers of Bio-Gide® are strongly hydrophilic. As a result, once moistened, the membrane adapts very well to the surgical site.

Bio-Gide^® bilayer design, cross section (SEM 100x)

The Bio-Gide® membrane consists of collagen types I and III which have been prepared to result in a bilayer membrane. The dense superior membrane layer, which faces the soft tissue, is cell occlusive and prevents invasion of soft connective tissue cells into the membrane protected space. The porous inferior layer, which faces the bony defect, consists of loosely arranged collagen fibers which act to stabilize the clot and enable bone cells to become integrated into the membrane.

The dense cell-occlusive layer is a barrier to soft tissue ingrowth and serves as a soft tissue scaffold (blue arrows). Granulation cells adhere to the natural collagen surface.

The porous side of the membrane is an open-pore, three-dimensional collagen matrix, which promotes cell integration (white arrows).

High similarity of Bio-Gide^® to human collagen membranes

Human Schneiderian membrane dissolved on the bony side. SEM view 2000x (Prof. K. Brenner, Anatomy Institute, LMU Munich)

Bio-Gide® - natural collagen structure (SEM 2000x)

Advantages of Bio-Gide^®

*Material*	*Properties*		Results

Tear-proof fibrous tissue structure	May be trimmed to desired size/shape and subsequently fixed in place either by adherence or fixation with pins/sutures		Easy to handle and perfect adaptation to the defect

Matrix with a bilayer structure		The smooth cell-occlusive layer forms a natural barrier against soft connective tissue cells The porous layer favors bone tissue integration	Long term undisturbed bone regeneration
Matrix with a bilayer structure

High-tech purified collagen-fibers		Accelerate bone cell adherence and blood clot stabilization Resorption without irritation of the tissue by acid formation	Favorable soft tissue healing Single step surgery

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