View the Package Insert:
United States
Canada - English
Canada - FrenchTo view a presentation about GEM 21S®, click here.
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| Mechanism of Action of GEM 21S® in an Osseous Wound. | ||||||||||
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| Important Safety Information. View the Package Insert: United States Canada - English Canada - FrenchTo view a presentation about GEM 21S®, click here. |
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| 1. Following thorough debridement of the osseous defect, it is completely filled with GEM 21S®. Initial release of PDGF occurs within minutes of grafting. PDGF is released from the β-TCP matrix into the surrounding environment. PDGF then binds to specific cell surface receptors on target cells initiating a cascade of intracellular signaling pathways. | ||||||||||
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| 2. PDGF - induced intracellular events lead to directed cell migration or chemotaxis and cell proliferation of osteoblasts, fibroblasts and cementoblasts. (Based on in vitro and in vivo data.) | ||||||||||
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| 3. Proliferation of osteoblasts, fibroblasts and cementoblasts leads to increased matrix synthesis, resulting in formation of new alveolar bone, periodontal ligament and cementum. (Based on in vitro and in vivo data.) | ||||||||||
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| 4. Clinical data suggests that over time (after approximately 6 months), maturation of supporting alveolar bone, cementum, and periodontal ligament occurs. The end result is enhanced bone and periodontal regeneration and retention of the natural tooth. | ||||||||||
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| 5. The goal of using GEM 21S® is to restore normal esthetics., anatomic form and function. | ||||||||||