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PDGF is one of the main growth factors found in the body and has a well established safety and effectiveness record in medicine as a wound healing agent. It exerts its effect primarily through the recruitment of cells within the surrounding matrix. Extensive in vitro and animal studies have demonstrated PDGF's potent chemotactic (directed cell migration) and mitogenic (proliferative) effects on cells derived from bone and periodontal ligament.

Following release at the wound site, PDGF stimulates:

 Chemotaxis (directed cell migration)
 Mitogenesis (bone and periodontal ligament cell proliferation)
 Matrix formation (e.g. collagen for new tissue formation)

It has also been shown to promote regeneration of periodontal tissues including bone, cementum and periodontal ligament in human clinical and histological studies.
Important Safety Information.

View the Package Insert:
 United States
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To view a presentation about GEM 21S®, click here.
Safety
The safety of PDGF has been demonstrated in multiple clinical trials and eight years of commercial use as a skin wound healing product for diabetic patients. The following tests have confirmed GEM 21S® to be biocompatible and safe:
In vitro cytotoxicty
 Sensitization
 Intracutaneous reactivity 		Acute systemic toxicity
 Genotoxicity
 Muscle implantation