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GEM 21S® is indicated to treat periodontally related defects, including:

Intrabony periodontal defects
Furcation periodontal defects
Gingival recession associated with periodontal defects.

Following is a representative case with GEM 21S® Growth-factor Enhanced Matrix


Vertical Defect at Baseline Through 24 Months Post-Op
Case by:
Dr. Michael McGuire
Important Safety Information.

View the Package Insert:
United States
Canada - English
Canada - French

To view a presentation about
GEM 21S®, click here.

GEM 21S® in place.
Baseline 9 mm probing depth and 8 mm deep by 3 mm wide, 2-wall intrabony defect on the distal of tooth #19.
Representative cases from the GEM 21S® pivotal trial:
Case 1
Case 2
Case 3
Case 4
Case 5
6 months post-operative, a 3 mm probing depth is observed.
Pre-operative radiograph 6 month post-operative radiograph demonstrating increased radiopacity on the distal surface of the tooth root. 12 month post-operative radiograph
24 month post-operative radiograph demonstrates complete fill of the intrabony defect with a normal bone trabecular pattern. Note the presence of the lamina dura along the distal root.