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Preclinical Studies

Camelo M, Nevins, ML, Schenk RK, Lynch SE, Nevins M. Periodontal Regeneration Can be Achieved in Human Class II Furcations using Purified Recombinant Human Platelet-Derived Growth Factor BB (rhPDGF-BB) with Bone Allograft. Int J Periodont Rest Dent 2003 June;23:213-225. View Abstract

Park JB, Matsuura M, Han KY, Norderyd 0, Un WL, Genco RJ, Cho MI. Periodontal regeneration in class III furcation defects of beagle dogs using guided tissue regenerative therapy with platelet- derived growth factor. J Periodontol 1995 Jun;66(6):462-77. View Abstract

Park EJ, Kim ES, Weber HP, Wright RF, Mooney DJ. Improved bone healing by angiogenic factor-enriched platelet-rich plasma and its synergistic enhancement by bone morphogenetic protein-2. Int J Oral Maxillofac Implants. 2008 Sep-Oct;23(5):818-26. View Abstract

Lin Z, Sugai JV, Jin Q, Chandler LA, Giannobile WV. Platelet-derived growth factor-B gene delivery sustains gingival fibroblast signal transduction. J Periodontal Res. 2008 Aug;43(4):440-9. View Abstract

Trombelli L, Farina R. Clinical outcomes with bioactive agents alone or in combination with grafting or guided tissue regeneration. J Clin Periodontol. 2008 Sep;35(8 Suppl):117-35. Review.  View Abstract

Fagan MC, Owens H, Smaha J, Kao RT. Simultaneous hard and soft tissue augmentation for implants in the esthetic zone: report of 37 consecutive cases. J Periodontol. 2008 Sep;79(9):1782-8.  View Abstract

Simion M, Rocchietta I, Monforte M, Maschera E. Three-dimensional alveolar bone reconstruction with a combination of recombinant human platelet-derived growth factor BB and guided bone regeneration: a case report. Int J Periodontics Restorative Dent. 2008 Jun;28(3):239-43.  View Abstract

Agis H, Bauer M, Knebl G, Watzek G, Gruber R. Effects of platelet-derived growth factor isoforms on plasminogen activation by periodontal ligament and gingival fibroblasts.  J Periodontal Res. 2008 Jun;43(3):334-42.  View Abstract

Byun HY, Wang HL. Sandwich bone augmentation using recombinant human platelet-derived growth factor and beta-tricalcium phosphate alloplast: case report.  Int J Periodontics Restorative Dent. 2008 Feb;28(1):83-7.  View Abstract

Fagan MC, Miller RE, Lynch SE, Kao RT. Simultaneous augmentation of hard and soft tissues for implant site preparation using recombinant human platelet-derived growth factor: a human case report  Int J Periodontics Restorative Dent. 2008 Feb;28(1):37-43.  View Abstract

Rocchietta I, Dellavia C, Nevins M, Simion M.Bone. Regenerated via rhPDGF-BB and a deproteinized bovine bone matrix: backscattered electron microscopic element analysis.  Int J Periodontics Restorative Dent. 2007 Dec;27(6):539-45.  View Abstract

Nevins M, Hanratty J, Lynch SE. Clinical results using recombinant human platelet-derived growth factor and mineralized freeze-dried bone allograft in periodontal defects.  Int J Periodontics Restorative Dent. 2007 Oct;27(5):421-7.  View Abstract

Belal MH, Watanabe H, Ichinose S, Ishikawa I. Effect of Er:YAG laser combined with rhPDGF-BB on attachment of cultured fibroblasts to periodontally involved root surfaces.  J Periodontol. 2007 Jul;78(7):1329-41.  View Abstract

Simion M, Rocchietta I, Dellavia C. Three-dimensional ridge augmentation with xenograft and recombinant human platelet-derived growth factor-BB in humans: report of two cases. Int J Periodontics Restorative Dent. 2007 Apr;27(2):109-15. View Abstract

Lynch S, Wisner-Lynch L, Nevins M , Nevins ML. A New Era in Periodontal and Periimplant Regeneration: Use of Growth Factor Enhanced Matrices Incorporating rhPDGF. Compend Contin Educ Dent 2006 Dec; 27: (12):672-679. View Abstract

Belal MH, Watanabe H, Ichinose S, Ishikawa I. A Time-dependant Effect of PDGF-BB on Adhesion and Growth of Cultured Fibroblasts to Root Surfaces. Oral Dis 2006 Nov; 12 (6):543-552. View Abstract

Rosen PS. Using Recombinant Platelet-Derived Growth Factor To Facilitate Wound Healing. Compend Contin Educ Dent 2006 Sept; 27 (9) 520-525. View Abstract 

Simion M, Rocchietta I, Kim D, Nevins M, Fiorelline J. Vertical Ridge Augmentation by Means of Deproteinized Bovine Bone Block and Recombinant Human Platelet-Derived Growth Factor- BB: A Histologic Study in a Dog Model. Int J Periodontics Restorative Dent 2006 Oct; 26 (5): 415 - 423. View Abstract

Wisner-Lynch LA. From Passive to Active: Will Recombinant Growth Factor Therapeutics Revolutionize Regeneration? Int J Periodontics Restorative Dent 2006 Oct; 26 (5): 409–411. View Abstract

Sarment DP, Cooke JW, Miller SE, Jin Q, McGuire MK, Kao RT, McClain PK, McAllister BS, Lynch SE, Giannobile WV. Effect of rhPDGF-BB on bone turnover during periodontal repair. J Clin Periodontol 2006; 33:135–140. View Abstract

Bateman J, Intini G, Margarone J, Goodloe S, Bush P, Lynch S, Dziak R. Platelet-Derived Growth Factor Enhancement of Two Alloplastic Bone Matrices. J Periodontol 2005;76:1833-1841. View Abstract

Okuda K, Kawase T, Momose M, Murata M, Saito Y, Suzuki H, Wolff L, Yoshie H. Platelet Rich Plasma Contains High Levels of Platelet-Derived Growth Factor and Transforming Growth Factor-β and Modulates the Proliferation of Periodontally Related Cells In Vitro. J Periodontol 2003;74:849-857. View Abstract

Nevins M, Camelo M, Nevins ML, Schenk R, Lynch SE. Periodontal Regeneration in Humans Using Recombinant Human Platelet-Derived Growth Factor BB (rhPDGF-BB) and Allogenic Bone. J Periodontol 2003 Sept.;74:1282-1292.  View Abstract

Papadopoulos CE, Dereka XE, Vavouraki EN, Vrotsos IA. In vitro Evaluation of the Mitogenic Effect of Platelet-Derived Growth Factor-BB on Human Periodontal Ligament Cells Cultured with Various Bone Allografts. J Periodontol 2003 Apr;74(4):45 1-7. View Abstract

Kawase T, Okuda K, Wolff LF and Yoshie H. Platelet-rich plasma-derived fibrin clot formation stimulates collagen synthesis in periodontal ligament and osteoblastic cells in vitro. J Periodontol 2003 June;74:858-864. View Abstract

Lee JY, Nam SH, Im SY, Park YJ, Lee YM, Seol YJ, Chung CP, Lee SJ. Enhanced bone formation by controlled growth factor delivery from chitosan-based biomaterials. J Control Release 2002;78:187-97. View Abstract

Zhu Z, Lee CS, Tejeda KM, Giannobile WV. Gene transfer and expression of platelet-derived growth factors modulate periodontal cellular activity. J Dent Res 2001 Mar;80(3):892-7. View Abstract

Parkar MH, Kuru L, Giouzeli M, Olsen I. Expression of growth-factor receptors in normal and regenerating human periodontal cells. Arch Oral Biol 2001 Mar;46(3):275-84. View Abstract

Ivanovski S, Haase HR, Bartold PM. Isolation and characterization of fibroblasts derived from regenerating human periodontal defects. Arch Oral Biol 2001 Aug;46(8):679- 88. View Abstract 
 
Mumford JH, Carnes DL, Cochran DL, Oates TW. The effects of platelet-derived growth factor-BB on periodontal cells in an in vitro wound model. J Periodontol 2001 Mar;72(3):331-40. View Abstract

Stephan E, Renjen R, Lynch S, Dziak R. Platelet-Derived Growth Factor Enhancement of a Mineral-Collagen Bone Substitute. J Periodontol 2000;71:1887-1892. View Abstract

Meraw SJ, Reeve CM, Lohse CM, Sioussat TM. Treatment of peri-implant defects with combination growth factor cement. J Periodontol 2000 Jan;71(1):8-13. View Abstract

Gamal AY, Maithot JM. The effect of local delivery of PDGF-BB on attachment of human periodontal ligament fibroblasts to periodontitis-affected root surfaces--in vitro. J Clin Periodontol 2000 May;27(5):347-53. View Abstract

Hobbs HC, Rowe DJ, Johnson PW. Periodontal ligament cells from insulin-dependent diabetics exhibit altered alkaline phosphatase activity in response to growth factors. J Periodontol 1999 Jul;70(7):736-42. View Abstract

Jiang D, Dziak R, Lynch SE, Stephan EB. Modification of an osteoconductive anorganic bovine bone mineral matrix with growth factors. J Periodontol 1999;70:834-9. View Abstract

Gamal AY, Mailhot JM, Garnick JJ, Newhouse R, Sharawy MM. Human periodontal ligament fibroblast response to PDGF-BB and IGF-1 application on tetracycline HCI conditioned root surfaces. J Clin Periodontol 1998 May;25(5):404-12. View Abstract

Howell TH, Fiorellini JP, Paquette DW, Offenbacher S, Giannobile WV and Lynch SE. A phase I/II clinical trial to evaluate a combination of recombinant human platelet derived growth factor-BB and recombinant human insulin-like growth factor-I in patients with periodontal disease. J Periodontol 1997 Dec;68(12):1 186-93. View Abstract

Bartold PM, Raben A. Growth factor modulation of fibroblasts in simulated wound healing. J Periodontal Res 1996 Apr;31(3):205-16. View Abstract

Giannobile WV, Hernandez RA, Finkelman RD, Ryan S, Kiritsy CP, D'Andrea M and Lynch SE. Comparative effects of platelet-derived growth factor-BB and insulin-like growth factor-I, individually and in combination, on periodontal regeneration in Macaca fascicularis. J Periodontal Res 1996 Jul;31(5):301-12. View Abstract

Oates TW, Kose KN, Xie JF, Graves UT, Collins JM, Cochran DL. Receptor binding of PDGF-AA and PDGF-BB, and the modulation of PDGF receptors by TGF-beta, in human periodontal ligament cells. J Cell Physiol 1995 Mar;162(3):359-66. View Abstract

Cho MI, Lin WL, Genco RJ. Platelet-derived growth factor-modulated guided tissue regenerative therapy. J Periodontol 1995 Jun;66(6):522-30. View Abstract

Oates TW, Rouse CA, Cochran DL. Mitogenic effects of growth factors on human periodontal ligament cells in vitro. J Periodontol 1993 Feb;64(2):142-8. View Abstract
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