There is an extraordinary solid scientific background on Bio-Oss® including worldwide research at more than 100 universities, more than 500 publications, clinical long-term results for 15 years and more than 1,500,000 patients treated.
Peri-Implant Defects
Sinus Floor Augmentation
Ridge Preservation
Ridge Augmentation
Ridge Reconstruction
Product Characteristics
Market Research
Sculean A, Jepsen S, Biomaterials for the Reconstructive Treatment of Periodontal Intrabony Defects. Part I. Bone Grafts and Bone Substitutes. Perio, 2004; 1.
Sculean A, Stavropoulos A, Windisch P, Keglevich T, Karring T, Gera L, Healing of Human Intrabony Defects Following Regenerative Periodontal Therapy with a Bovine-Derived Xenograft and Guided Tissue Regeneration. Clin Oral Investigations, 2004; 8: 70-74.
Tonetti MS, Cortellini P, Lang NP, Suvan JE, Adriaens P, Dubravec D, Fonzar A, Fourmousis I, Rasperini G, Rossi R, Silvestri M, Topoll H, Walkamm B, Zybutz M. Clinical Outcomes Following Treatment of Human Intrabony Defects with GTR/Bone Replacement Material or Access Flap Alone. A Multicenter Randomized Controlled Clinical Trial. J Clin Periodontol, 2004; 31:770-776
Nevins ML, Camelo M, Lynch SE, Schenk RK, Nevins M. Evaluation of Periodontal Regeneration Following Grafting Intrabony Defects with Bio-Oss Collagen®: A Human Histologic Report. Int J Periodontics Restorative Dent 2003: 9-17.
Lekovic V, Camargo P, Weinlander M, Effectiveness of a Combination of Platelet-Rich Plasma, Bovine Porous Bone Mineral and Guided Tissue Regeneration in the Treatment of Mandibular Grade II Molar Furcations in Humans. J Clin Periodontol 2003; 30: 746-751.
Sculean A, Berakdar M, Chiantella GC, Donos N, Arweiler NB, Breux M, Healing of Intrabony Defects Following Treatment with a Bovine-Derived Xenograft and Collagen Membrane. A Controlled Clinical Study. J Clin Periodontol 2003: 30: 73-80.
Zitzmann N, Rateitschak-Pluss E, Marinello C, Treatment of Angular Bone Defects with a Composite Bone Grafting Material in Combination with a Collagen Membrane. J Periodontol 2003; 74: 687-694.
Zucchelli G, Amore C, Montebugnoli L, De Sancitis M, Enamel Matrix Proteins and Bovine Porous Bone Mineral in the Treatment of Intrabony Defects: A Comparative Controlled Clinical Trial. J Periodontol, 2003; 74: 1725-1735.
Yamada S, Shima N, Kitamura H, Sugito H. Effect of Xenographic Bone Graft with Collagen Barrier Membrane on Periodontal Regeneration. Int J Periodontics Restorative Dent 2002, 22: 389-397.
Pripatnanont P, Nuntanaranont T, Chungpanich. Two Uncommon Uses of Bio-Oss® for GTR and Ridge Augmentation Following Extractions: Two Case Reports. Int J Periodontics Restorative Dent 2002 22: 278-285.
Re S, Corrente G, Abundo R, Cardaropoli D. Orthodontic Movement into Bone Defects Augmented with Bovine Bone Mineral and Fibrin Sealer: A Reentry Case Report. Int J Periodontics Restorative Dent 2002; 22:138-145.
Scheyer ET, Velasquez-Plata D, Brunsvold MA, Lasho DJ, Mellonig JT. A Clinical Comparison of a Bovine-Derived Xenograft Used Alone and in Combination With Enamel Matrix Derivative for the Treatment of Periodontal Osseous Defects in Humans. J Periodontol 2002, 73:423-432.
Sculean A, Chiantella GC, Windisch P, Gera I, Reich E. Clinical Evaluation of an Enamel Matrix Protein Derivative (Emdogain) Combined with a Bovine-Derived Xenograft (Bio-Oss®) for the Treatment of Intrabony Periodontal Defects in Humans. Int J Periodontics Restorative Dent 2002; 22:259-267.
Velasques-Plata D, Scheyer ET, Mellonig JT, Clinical Comparison of an Enamel Matrix Derivative Used alone or in Combination with a Bovine-Derived Xenograft for the treatment of Periodontal Osseous Defects in Humans. J Periodontol 2002; 73: 433-440.
Camelo M, Nevins ML, Lynch SE, Schenk RK, Simion M, Nevins M. Periodontal Regeneration with an Autogenous Bone – Bio-Oss® Composite Graft and a Bio-Gide® Membrane. Int J Periodontics Restorative Dent 2001; 21(2):109-119.
Houser B, Mellonig JT, Brunsvold M, Cochran D, Meffert R, Alden M. Clinical Evaluation of Anorganic Bovine Bone Xenograft with a Bioabsorbable Collagen Barrier in the Treatment of Molar Furcation Defects. Int J Periodontics Restorative Dent 2001; 21(2):161-169.
Lekovic V, Camargo P, Weinlander M, Kenney E, Vasilic N, Combination Use of Bovine Porous Bone Mineral, Enamel Matrix Proteins, and a Bioabsorbable Membrane in Intrabony Periodontal Defects in Humans. J Periodontol 2001; 72: 583-589.
Paolantonio M, Scarano A, Di Placido G, Tumini V, D'Archivio D, Piatelli A, Periodontal Healing in Humans Using Anorganic Bovine Bone and Bovine Peritoneum-Derived Collagen Membrane: A Clinical and Histological Case Report. Int J Periodontics Restorative Dent 2001; 21: 505-515.
Pietruska MD, A comparative Study on the Use of Bio-Oss and Enamel Matrix Derivative (Emdogain) in the Treatment of Periodontal Defects. Eur J Oral Sci 2001, 109: 178-181.
Alpar B, Leyhausen G, Gunay H, Geurtsen W, Compatibility of Resorbable and Non Resorbable Guided Tissue Regeneration Membranes in Cultures of Primary Human Periodontal Ligament Fibroblasts and Human Osteoblast-like Cells. Clin Oral Invest 2000; 4: 219-225.
Lekovic V, Camargo PM, Weinlander M, Nedic M, Aleksic Z, Kenney EB, A Comparison Between Enamel Matrix Proteins Used Alone in Combination with Bovine Porous Bone Mineral in the Treatment of Intrabony Periodontal Defects in Humans. J Periodontol 2000; 71 (7): 1110-1116.
Mellonig JT. Human Histologic Evaluation of a Bovine-Derived Bone Xenograft in the Treatment of Periodontal Osseous Defects. Int J Periodontics Restorative Dent 2000; 20(1):18-29.
Camargo PM, Lekovic V, Weinlander M, Nedic M, Vasilic N, Wolinsky LE, Kenney EB, A Controlled Re-entry Study on the Effectiveness of Bovine Porous Bone Mineral Used in Combination with a Collagen Membrane of Porcine Origin in the Treatment of Intrabony Defects in Humans. J Clin Periodontol 2000; 27: 889-896
Lundgren D, Slotte C, Reconstruction of Anatomically Complicated Periodontal Defects Using a Bioresorbable GTR barrier Suorted by Bone Mineral. A Six Months Follow-up Study of Six Cases. J Clin Periodontol 1999; 26: 56-62.
Richardson CR, Mellonig JT. Clinical Evaluation of Bio-Oss: A Bovine Derived Xenograft for the Treatment of Periodontal Osseous Defects in Humans. J Clin Periodontol 1999.
Ohazama A, Kitamura H, Suzuki M, Yamada S, Hasegawa K, The Clinical Evaluation of Periodontal Surgery with Porous Bone Graft Material (Bio-Oss®) and Collagen Membrane (Bio-Gide). Journal of Japanese Society of Periodontol 1999; 41 (2):153-165.
Camelo M, Nevins ML, Schenk RK, Rasperini G, Simion M, Lynch SE, Nevins M. Clinical, Radiographic and Histologic Evaluation of Human Periodontal Defects Treated with Bio-Oss and Bio-Gide. Int J Periodontics Restorative Dent 1998; 18(4):3-13.
Weisen M, Oringer RJ, Lynch SE, Iacono VJ. Efficacy of Bovine Bone Mineral in Vertical Osseous Defects. J Periodontology. Submitted [Abstract published and presented at IADR Meeting, Nice, France 1998.
Schmitt JM, Buck DC, Joh SP, Lynch E, Hollinger JO, Comparison of Porous Bone Mineral and Biologically Active Glass in Critical-Sized Defects. J Periodontol 1997; 68: (11): 1043-1053.
Clergeau LP, Danan M, Clergeau-Guerithault S, Brion M, Healing Response to Anorganic Bone Implantation in Periodontal Intrabony Defects in Dogs. J Periodontol 1996; 67:140-149
Sigurdsson ThJ, Nygaard L, Tatakis DN, Fu E, Turek ThJ, Jin L, Wozney JM, Wikesjo UME, Periodontal Repair in Dogs: Evaluation of rhBMP-2 Carriers. Int J Periodontics Restorative Dent 1996; 16 (6): 525-637.
Anorganic Bone Plus Collagen in the Treatment of Periodontal Intrabony Defects [in humans]. American Inst. Oral Biol Proceedings 1996
Brion M, Clergeau LP, Clergeau Gueritault S, Danan, Anorganic Bone Plus Collagen in the Treatment of Periodontal Intrabony Defects. The American Institute of Oral Biology, the 52nd Annual Meeting, Palm Springs, CA, October 20-24, 1995.
Cohen RE, Mullarky RH, Anorganic Bovine Bone and Bovine /Collagen Composites in Regenerative Periodontal Therapy. Biological Therapies in Dentistry 1993; 9 (1):3-4.
Brion M, et al., Evaluation of Anorganic Bone Plus Collagen in Infra Bony Defects. J Dent Res 1992; 71 (4): abstract 76.
Brion M, Clergeau S, Cohen P, et al., Anorganic Bone Plus Collagen in the Treatment of Periodontology, Abstract Research Forum, April 15, 1990.
Brion M, Radiographic Evaluation of Anorganic Bovine Bone Plus Collagen (Bio-Oss Collagen®) in Periodontal Intrabony Lesions. The 46th Annual Meeting, October 27-31, 1989, Palm Springs.
Artzi Z, Nemcovsky C. Tal H. Efficacy of Porous Bovine Bone Mineral in Various Types of Osseous Deficiencies Clinical Observations and Literature Review. Int J Periodontics Restorative Dent 2001; 21(4):395-405.
Zitzmann N, Scharer P, Marinello C. Long-Term Results of Implants Treated with Guided Bone Regeneration: A 5-Year Prospective Study. Int J Oral Maxillofac Implants 2001; 16(3): 355-366
Artzi Z. Coronal Ridge Augmentation in the Absence of Bilateral Bony Plates Around a Pathologically Denuded Implant Surface. Int J Periodontics Restorative Dent 2000; Vol. 20.
Hockers T, Abensur D, Valentini P, Legrand R, Hammerle, CHF. The Combined Use of Bioresorbable Membranes and Xenografts in the Treatment of Bone Defects Around Implants. A study in beagle dogs. J Dent Res, 1998;77; (IADR Abstract)
Hurzeler MB, et al. Evaluation of a New Bioresorbable Barrier to Facilitate GBR Around Exposed Implant Threads. An Experimental Study in the Monkey. Int J Oral Max Surg 1998;27:315-320.
Abensur D, Valentini P, Hockers P, Missika P, Legrand R, Hammerle CH, Utilization of an Absorbable Membrane (Bio-Gide®) for the Treatment of Peri-Implant Defects: A Dog Study. Int J Oral Maxillofac Implants 1997; 12 (2):227.
Lindhe J, Berglundh T. Healing Around Implants Placed in Bone Defects Treated with Bio-Oss. An Experimental Study in the Dog. Clin Oral Impl Res 1997; 8:117-124.
Boyne P. Osseous Reconstruction of the Maxilla and the Mandible: Surgical Techniques Using Titanium Mesh and Bone Mineral. Quintessence Publishing, Carol Stream, IL, 1997.
Hurzeler MB, Kohal RJ, Mota L, Naghshbondi J, Caffesse RG. A New Bioresorbable Barrier to Facilitate Guided Bone Regeneration. J Dent Res, 1997; 76 (IADR Abstracts).
Zitzmann NV, Scharer MS. Resorbable Versus Nonresorbable Membranes in Combination with Bio-Oss for Guided Bone Regeneration. Int J Oral Maxillofac Implants 1997; 12: 844-853.
Hurzeler MB, Strub JF, Guided Bone Regeneration Around Exposed Implants: A New Bioresorbable Device and Bioresorbable Membrane Pins. The Implant Report 1995; 7 (9): 37-47.
Hallman M, Nordin T, Sinus Floor Augmentation with Bovine Hydroxyapatite Mixed with Fibrin Glue and Later Placement of Nonsubmerged Implants. Int J Oral Maxillofac Implants, 2004; 19: 222-227.
John HD, Wenz B, Histomorphometric Analysis of Natural Bone Mineral for Maxillary Sinus Augmentation. Int J Oral Maxillofac Implants, 2004; 19: 199-207.
Piattelli M, Orsini G. Scarano A, Degidi M, Perrotti V, Piatelli A, Maxillary Sinus Augmentation with Bio-Oss. 13th Annual Scientific Meeting European Association of Osseointegration, 2004, September 16-18, Paris
Scarano A, Pecora G, Piattelli A, Osseointegration in a Sinus Augmented With Bovine Porous Bone Mineral: Histological Results in an Implant retrieved 4 years after insertion. A Case Report. J Periodontol, 2004; 75:1161-1166.
Schlegel KA, Eitner S, Schultze-Mosgau S, Wiltfang J, Comparative Clinical Results after Implant Placement in the Posterior Maxilla with and Without Sinus Augmentation. Implantologie, 2004; 12:49-66.
Schwartz-Arad D, Herzberg R, Dolev E, The Prevalence of Surgical Complications of the Sinus Graft Procedure and Their Impact on Implant Survival. J Periodontol, 2004; 75:511-516.
Toffler M, Osteotome-Mediated Sinus Floor Elevation: A Clinical Report. Int J Oral Maxillofac Implants, 2004; 19:266-273.
Bragger U, Gerber C, Joss A, Haenni S, Meier A, Hashorva E, Lang NP, Patterns of Tissue Remodeling After Placement of ITI Dental Implants Using an Osteotome Technique: A Longitudinal Radiographic Case Cohort Study. Clin Oral Impl Res, 2004; 15: 158-166
Maiorana C, Sommariva L, Brivio P, Sigurta D, Santoro F, Maxillary Sinus Augmentation with Anorganic Bovine Bone (Bio-Oss) and Autologous Platelet-Rich Plasma: Preliminary Clinical and Histologic Evaluations. Int J Periodontics Restorative Dent 2003; 23: 227-235.
Rodrigquez A, Anastassov G, Lee H, Buchbinder D, Wettan H, Maxillary Sinus Augmentation with Deproteinated Bovine Bone and Platelet Rich Plasma with Simultaneous Insertion of Endosseous Implants. J Oral Maxillofacial Surg 2003; 61: 157-163.
Sartori S, Silvestri M, Forni F, Icaro Cornaglia A, Tesei P, Cattaneo V, Ten-Year Follow-up in a Maxillary Sinus Augmentation Using Anorganic Bovine Bone (Bio-Oss®). A Case Report With Histomorphometric Evaluation. Clin Oral Impl Res 2003, 14:369-372.
Schlegel KA, Fichtner G, Schultze-Mosgau S, Wiltfang J, Histologic Findings in Sinus Augmentation with Autogenous Bone Chips Versus a Bovine Bone Substitute. Int J Oral Maxillofac Implants 2003; 18: 53-58.
Tadjoedin E. S., de Lange G. L., Bronckers A., Lyaruu D. M., Burger E. H. Deproteinized Cancellous Bovine Bone (Bio-Oss) as Bone Substitute for Sinus Floor Elevation. A Retrospective, Histomorphometrical Study of Five Cases. J Clin Periodontol 2003; 30: 261-270.
Armand S, Kirsch A, Sergent C, Kemoun P, Brunel G, Radiographic and Histologic Evaluation of a Sinus Augmentation With Composite Bone Graft: A Clinical Case Report. J Periodontol 2002; 73, (9): 1082-1088.
Artzi Z, Nemcovsky C, Dayan D, Bovine-HA Spongiosa Blocks and Immediate Implant Placement in Sinus Augmentation Procedures. Histopathological and Histomorphometric Observations on Different Histological Stainings in 10 Consecutive Patients. Clin Oral Impl Res 2002; 13: 420-427.
Froum S, Wallace S, Tarnow D, Cho S, Effect of Platelet-Rich Plasma on Bone Growth and Osseointegration in Human Maxillary Sinus Grafts: Three Bilateral Case Reports. Int J Periodontics Restorative Dent 2002; 22, (1): 45-53.
Lekovic V, Camargo P, Weinlander M, Vasilic N, Kenney EB, Comparison of Platelet-Rich Plasma, Bovine Porous Bone Mineral and Guided Tissue Regeneration Versus Platelet-Rich Plasma and Bovine Porous Bone Mineral in the Treatment of Intrabony Defects: A Reentry Study. J Periodontol 2002; 73 (2): 198-205,
Kasabah S, Simunek A, Krug J, Cevallos Lecaro M, Maxillary Sinus Augmentation Using Deproteinized Bovine Bone (Bio-Oss) and Impladent Dental Implant System. Part 1. Comparison Between One-Stage and Two-Stage Procedure. Acta Medica 2002; 45 (3): 115-118.
Artzi Z, Nemcovsky C, Tal H, Dayan D, Histopathological Morphometric Evaluation of 2 different Hydroxyapatite-Bone Derivatives in Sinus Augmentation Procedures: A Comparative Study in Humans. J Periodontol 2001; 72 (7): 911-920.
Yildirim M, Spiekermann H, Handt S, Edelhoff D, Maxillary Sinus Augmentation with the Xenograft Bio-Oss and Autogenous Intraoral Bone for Qualitative Improvement of the Implant Site: A Histologic and Histomorphometric Clinical Study in Humans. Int J Oral Maxillofac Implants. 2001;16:23-33.
Chyplyk L, Grossschmidt K, Weinlander M, Plenk H jr, Histomorphometric Analysis of a Sinus Augmentation with Bio-Oss and Chinbone Grafts: A case report. Implantologie 2000; 4:419-430.
Maiorana C, Redemagni M, Rabagliati M, Saline S, Treatment of Maxillary Ridge Resorption by Sinus Augmentation with Iliac Cancellous Bone, Anorganic Bovine Bone and Endosseous Implants: A Clinical and Histologic Report. Int J Oral Maxillofac Implants 2000; 15 (6): 873-878.
Fugazzotto, P., GBR Using Bovine Bone Matrix and Resorbable and Nonresorbable Membranes. Part 2: Clinical Results. Int J Periodontics Restorative Dent 2003; Vol 23, 6: 599-605.
Fugazzotto, P., GBR Using Bovine Bone Matrix and Resorbable and Nonresorbable Membranes. Part 1: Histologic Results. Int J Periodontics Restorative Dent 2003; Vol 23,4: 361-369
Hallman M, Sennerby L, Lundgren S. A Clinical and Histologic Evaluation of Implant Integration in the Posterior Maxilla After Sinus Floor Augmentation with Autogenous Bone, Bovine Hydroxyapatite, or a 20:80 mixture. Int J of Oral Maxillofac Implant Vol 17; 5 2002 p. 635
Tawil, G., Mawla M. Sinus Floor Elevation Using a Bovine Bone Mineral (Bio-Oss) With or Without the comcomitant Use of a Bilayered Collagen Barrier (Bio-Gide): A Clinical Report of Immediate and Delayed Implant Placement. Int J Oral Maxillofac Implants 2001; Vol 16, 5:713-721
Valentini P, Abensur D, Wenz B, Peetz M, Schenk R, Sinus grafting with porous bone mineral (Bio-Oss): a study on 15 patients. Int J of Periodontics Restorative Dent 2000; 20 (3): 245-252.
McAllister BS, Margolin MD, Cogan AG, Buck D, Hollinger JO, Lynch SE, Eighteen-Month Radiographic and Histologic Evaluation of Sinus Grafting with Anorganic Bovine Bone in the Chimpanzee. Int J Oral Maxillofac Implants 1999; 14:361-368
Piattelli M, Favero GA, Scarano A, Orsini G, Piatelli A, Bone Reactions to Anorganic Bovine Bone (Bio-Oss®) Used in Sinus Augmentation Procedures: A Histologic Long-Term Report of 20 Cases in Humans. Int J Oral Maxillofac Implants 1999; 14 (6): 835-840.
Terheyden H, Jepsen S, Moller B, Tucker MM, Rueger DC, Sinus Floor Augmentation With Simultaneous Placement of Dental Implants Using a Combination of Deproteinized Bone Xenografts and Recombinant Human Osteogenic Protein-1. A Histometric Study in Miniature Pigs. Clin Oral Impl Res 1999; 10: 1-12.
Fugazzotto PA, Vlassis J. Long Term Success of Sinus Augmentation Using Various Surgical Approaches and Grafting Materials. Int J Oral Maxillofac Implants 1998; 13:52-58.
Haas R, Donath K, Fodinger M, Watzek G, Bovine Hydroxyapatite for Maxillary Sinus Grafting: Comparative Histomorphometric Findings in Sheep. Clin Oral Impl Res 1998: 9:
107-116
Haas R, Mailath G, Dortbudak O, Watzek G. Bovine Hydroxylapatite for Maxillary Augmentation: Analysis of Interfacial Bond Strength of Dental Implants Using Pullout Tests. Clin Oral Impl Res 1998; 9: 117-122.
Margolin M et al. Maxillary Sinus Augmentation Iin the Non-Human Primate: A Comparative Radiographic and Histologic Study Between Recombinant Human Ssteogenic Protein One and Natural Bone Mineral. J Periodontol 1998; 69:911-919.
McAllister BS, Margolin MD, Cogan AG, Taylor M, Wollins J. Residual Lateral Wall Defects Following Sinus Grafting with Recombinant Human Osteogenic Protein or Bio-Oss in the Chimpanzee. Int J Periodontics Restorative Dent 1998;18: 227-239.
McAllister BS, Margolin M, Taylor M, Buck D, Hollinger J, Lynch S. Long Term Evaluation of Sinus Grafting with Bio-Oss in the Chimpanzee. J Dent Res 1998;77:769 (IADR abstract).
Valentini P, Abensur D, Densari D, Graziani JN, Hammerle CHF. [Human] Histological Evaluation of Bio-Oss in a 2-stage Sinus Floor Elevation and Implantation Procedure. Clin Oral Impl Res 1998; 9:59-64.
Zitzmann NU, Scharer P, Sinus Elevation Procedures in the Resorbed Posterior Maxilla. Comparison of the Crestal Lateral Aroaches. Oral Surg Oral Med Oral Pathol Oral Radio Endod. 85 (1): 8-17, 1998.
Haas R, Donath K, Fodinger M, Watzek G, Histomorphometric Results of Sinus Lift Procedures in Sheep Using Bovine Hydroxyapatite. 7th International Congress on Reconstructive Preprosthetic Surgery. Copenhagen, June 4-7, 1997: 59.
Hurzeler MB, Quinones CR, Kirsch A, Gloker C, Schupbach P, Strub JF, Caffesse RG, Maxillary Sinus Augmentation Using Different Grafting Materials and Dental Implants in Monkeys. Clin Oral Impl Res. 8: 476-486, 1997.
Valentini P, Abensur D. Maxillary Sinus Floor Elevation for Implant Placement with Demineralized Freeze-Dried Bone and Bovine Bone (Bio-Oss): A Clinical Study of 20 Patients. Int J Periodontics Restorative Dent 1997; 17:233-241.
Terheyden H, Jepsen S, Moller B, Tucker M, Rueger D, Maxillary Sinus Floor Augmentations Using Recombinant Human Bone Morphogenetic Protein 7 With Simultaneous Placement of Dental Implants. 7th International Congress on Reconstructive Preprosthetic surgery, Copenhagen, June 4-7 1997; 61.
Valentini P, Abensur D, Maxillary Sinus Floor Elevation for Implant Placement with Demineralized Freeze-Dried Bone and Bovine Bone (Bio-Oss): A Clinical Study of 20 Patients. Int J of Periodontics Restorative Dent: 17, (3): 233-241, 1997
Wheeler SL. Sinus Augmentation for Dental Implants: The Use of Alloplastic Materials. J Oral MaxSurg 1997; 55:1287-1293.
Hurzeler MB, Quinones CR, Kirsch A, Schupbach P, Strub JR, Caffesse RC, Maxillary Sinus Augmentation in Monkeys Using Bio-Oss as a Grafting Material. J Dent. Res 74 (AADR Abstracts), Oral & Maxillofacial Surgery/Periodontal Research, 193: 1995
Wetzel AC, Stich H, Caffesse R. Bone Apposition on to Oral Implants in the Sinus Area Filled with Different Grafting Materials: A Histologic Study in Beagle Dogs. Clin Oral Impl Res 1995.
Smiler DG, Johnson PW, Lozada JL, et al, Sinus Lift Grafts and Endosseous Implants. Dental Clinics of North America 36 (1): January 1992
Kirsch A., Sinus Floor Elevation and HA Augmentation with IMZ Implants. 4th International Congress on Preprosthetic Surgery, Palm Springs CA, April 18-20, 1991
Boyne PJ, Analysis of Performance of Root-Form Endosseous Implants Placed in the Maxillary Sinus. Journal of Long-Term Effects of Medical Implants, 3 (2): 143-159, 1993
Ridge Preservation
Carmagnola D, Adriaens P, Berglundh T, Healing of Human Extraction Sockets Filled with Bio-Oss®. Clin Oral Impl Res 2003; 13:137-143.
Artzi Z, Tal H, Dayan D. Porous Bovine Bone Mineral in Healing of Human Extraction Sockets. Part 1: Histomorphometric Evaluations at 9 months. J Periodontol 2000; 71: 1015-1023.
Sclar A. Ridge Preservation for Optimum Esthetics and Function: The Bio-Col Technique. Supplement to The Compendium 1999; Vol 6, Number 1.
Boyne PJ, Chan G, Comparison of Porous Bone Mineral and HA in Maintenance of Alveolar Ridges in Man. 4th International Preprosthetic Surgery Conference, Palm Springs, CA April 18-20, 1991.
Boyne PJ, Burnham M, Devlin M, Effect on Bone Morphology and Alveolar Contour of the Socket Implantation of Hydroxylapatite. 4th International Preprosthetic Surgery Conference, Palm Springs, CA April 18-20, 1991
Ridge Augmentation
Ersanli S, Olgac V, Leblebicioglu B., Histologic Analysis of Alveolar Bone Following Guided Bone Regeneration. J Periodontol, 2004; 75: 750-756.
Norton M, Odell E, Thompson I, Cook R, Efficacy of Bovine Bone Mineral for Alveolar Augmentation: A Human Histologic Study. Clin Oral Impl Res, 2003;14: 775-783.
Artzi Z, Dayan D, Alpern Y, Nemcovsky C, Vertical Ridge Augmentation Using Xenogenic Material Supported by a Configured Titanium Mesh: Clinicohistopathologic and Histochemical Study. Int J Oral Maxillofac Implants 2003; 18:440-446.
Proussaefs P, Lozada J, Kleinmann A, Rohrer M, McMillan PJ, The use of Titanium Mesh in Conjuction with Autogenous Bone Graft and Inorganic Bovine Bone Mineral (Bio-Oss®) for Localized Alveolar Ridge Augmentation: A Human Study. Int J Periodontics Restorative Dent 2003; 23: 185-195.
Wojtowicz A, Chaberek S, Kryst L, urbanowska E, Ciechowicz K, Ostrowski K, Fourier and Fractal Analysis of Maxillary Alveolar Ridge Repair Using Platelet Rich Plasma (PRP) and Inorganic Bovine Bone. J Oral Maxillofac Surg, 2003; 18:556-560.
Araujo MG, Sonohara M, Hayacibara R, Cararopoli G, Lindhe J, Lateral Ridge Augmentation by the Use of Grafts Comprised of Autologous Bone or a Biomaterial. An Experiment in the Dog. J Clin Periodontol 2002; 29:1122-1133.
Piattelli A, Degidi M, Di Stefano D, Rubini C, Fioroni M, Strocchi R, Microvessel Density In Alveolar Ridge Regeneration with Autologous and Alloplastic Bone. Implant Dent 2002;11:370-375.
Pripatnanont P, Numtanaranont T, Chungpanich S, Two Uncommon Uses of Bio-Oss® for GTR and Ridge Augmentation Following Extractions: Two Case Reports. Int J Periodontics Restorative Dent 2002; 22 (3): 567-573.
Proussaefs P, Lozada J, Rohrer M. A Clinical and Histologic Evaluation of a Block Onlay Graft in Conjunction with Autogenous Particulate and Inorganic Bovine Mineral (Bio-Oss): A Case Report. Int J Periodontics Restorative Dent, 2002, 22: 561-573.
Maiorana C, Santoro F. Maxillary and Mandibular Bone Reconstruction with Hip Grafts and Implants Using Frialit-2 Implants. Int J Periodontics Restorative Dent, 2002, 22: 221-229.
Proussaefs P, Lozada J, Kleinman A, Rohrer MD. The Use of Ramus Autogenous Block Grafts for Vertical Alveolar Ridge Augmentation and Implant Placement: A Pilot Study. Int J Oral Maxillofac Implants 2002; 17:238-248.
Zitzmann N, Scharer P, Marinello C, Schupach P, Berglundh T. Alveolar Ridge Augmentation with Bio-Oss®: A Histologic Study in Humans. Int J Periodontics Restorative Dentistry 2001; 21(3):289-294.
Maiorana C, Santoro F, Rabagliati M, Salina S. Evaluation of the Use of Iliac Cancellous Bone and Anorganic Bovine Bone in the Reconstruction of the Atrophic Maxilla with Titanium Mesh: A Clinical and Histologic Investigation. Int J Oral Maxillofac Implants 2001; 16: 427-432.
Kirsch A, Ackermann KL, Hutmacher D. Localized Ridge Augmentation by GBR - Long-Term Clinical and Histological Results. 7th International Congress on Reconstructive Preprosthetic Surgery, Copenhagen, June 4-7 1997: 61.
Jepsen S, Terheyden H, Vogler S, Tucker M, Rueger D, Mandibular Augmentation by Recombinant Human Osteogenic Protein-1. 7th International Congress on Reconstructeve Preprosthetic Surgery, Copenhagen, June 4-7 1997: 61.
Kay SA, Wisner-Lynch L, Marxer M, Lynch SE. Guided Bone Regeneration: Integration of a Resorbable Membrane and a Bone Graft Material. Pract Periodont Aesthet Den 1995; 9(2) 185-1934.
Romanos GE, Nentwig GN, Helmke U, Implantation in the Narrow Alveolar Ridge. Giornate Internazionali di Implantologia Orale, XV Congresso Nazionale A.N.I.O. Abano Terme Italy, 14-17 Aprile, 1994.
Nentwig GH, Nick I, Helmke U, Implantation in a Narrow Alveolar Process-Diagnosis Classification and Operative Procedure. Zeitschrift fur Zahnaztliche Implantologie, Band IX, 1993.
Anderson M, Womack M, Alveolar Ridge Maintenance Using Anorganic Bovine Bone. Department of Oral and Maxillofacial Surgery, Medical Center, Loma Linda University, 1987
Boyne PJ, Scheer PM, Osseointegration of Intraosseous Implants in Anorganic Bone Grafted & HA Implanted Mandibular Ridges. 2nd International Symposium, May 14-16 1987, Paper presented at Biomaterials meeting, NYC, June 1987.
Ridge Reconstruction
Boyne P. Osseous Reconstruction of the Maxilla and the Mandible: Surgical Techniques Using Titanium Mesh and Bone Mineral. Quintessence Publishing, Carol Stream, IL 1997 pp 1-100.
Perrott DH, Smith RA, Sharma AB, McArdle L, Maxillary and Mandibular Reconstruction in Preparation for Endosseous Implants. CDA Journal 1993; 21 (5) 39-43.
Boyne PJ, Comparison of Porous and Non-Porous Hydroxyapatite and Anorganic Xenografts in the Restoration of Alveolar Ridges. American Society for Testing and Materials. 1987, 359-369.
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Product Characteristics
Rothamel D, Schwarz F, Sculean A, Herten M, Scherbaum W, Becker J, Biocompatibility of Various Collagen Membranes in Cultures of Human PDL Fibroblasts and Human Osteoblasts-like Cells. Clin Oral Impl Res, 2004; 15: 443-449.
Benezra Rosen V, Hobbs LW, Spector M, The Ultrastructure of Anorganic Bovine Bone and Selected Synthetic Hydroxyapatites Used as Bone Graft Substitute materials. Biomaterials 2002; 23: 921-928.
Boyne P. Osseous Reconstruction of the Maxilla and the Mandible: Surgical Techniques Using Titanium Mesh and Bone Mineral. Quintessence Publishing Carol Stream, IL, 1997 (see Appendix I).
Kay S, Boyne P, Spector M, Lynch S. Natural Bone Mineral: An alternative to Current Bone Grafting Modalities. Portland Bone Symposium Proceedings 1997.
Spector M. Anorganic Bovine Bone and Ceramic Analogs of Bone Mineral as Implants to Facilitate Bone Regeneration. Clinics in Plastic Surgery 1994; 21:437-444.
McAllister BS, Margolin M, Taylor M, Buck D, Hollinger J, Lynsh S. Long Term Evaluation of Sinus Grafting with Bio-Oss in the Chimpanzee. J. Dent Res 1998; 77:769 (IADR Abstract).
Peetz M, Characterization of Xenogenic Bone Material In: Osseous Reconstruction of the Maxilla and the Mandible, Philip J. Boyne, Quintessence Publishing Co., Inc. Chicago: 87-100, 1997.
Berglundh T, Lindhe J. Healing Around Implants Placed in Bone Defects Treated with Bio-Oss. An Experimental Study in the Dog. Clin Oral Impl Res 1997; 8:117-124.
Benke D, Olah A, Möhler H. Protein-Chemical Analysis of Bio-Oss® Bone Substitute and Evidence on its Carbonate Content. Biomaterials 2001; 22:1005-1012.
Bunyaratavej P, Wang H, Collagen Membranes: A Review. J Periodontol 2001; 72 (2): 109-119.
Wenz B, Oesch B, Horst M. Analysis of the Risk of Transmitting Bovine Spongiform Encephalopathy through Bone Grafts Derived from Bovine Bone. Biomaterials 2001; 22:1599-1606.
Boyne PJ, Use of Porous Bone Mineral to Increase Bone Density. Mat Res Soc Symp Proc 1994; 331: 263-268.
Hammerle C, Lange NP, Bio-Oss®, a Natural Bone Mineral in Bone Regeneration. Journal de Parodontologie, Abstracts EuroPerio 1, Paris, 1994.
Peetz M, Properties of Biomaterials for Bone Regeneration. Proceedings Giornate Internazionali di Implantologia Orale, Abano Terme, April 14-17, 1994 Monduzzi Editore S.p.A. Bologna, Italy.
Schlegel KA, Fichtner G, Zimmermann M, Arnold M, Clinical and Histological Results with Bio-Oss®. International Symposium, Bone defects around teeth and implants, Leuven (Belgium), October 15-16, 1994.
Pauli Ch, Schlickewei W, Kuner EH, Schenk RK, Bovine Apatite: Its Value as a Bone Substitute. Osteologie aktuell VII, Hrsg: HJ Pesch, H. Stoss, B. Kummer, Springer Verlag: 288-291, 1993.
Bereiter H, Schlickewei W, Huggler AH, Kuner EH, Clincial Experience of Bio-Oss® Used for Various Purposes. Osteologie aktuell VII, Hrsg: H-J Pesch, H. Stoss, B. Kummer, Springer-Verlag: 300-302, 1993.
Bereiter H, Melcher GA, Gautier E, Huggler AH, Experience with Bio-Oss®, a Bovine Apatite, in Various Clinical Indications. Hefte zur Unfallheikunde, Heft 216, Hrsg. AH Huggler, EH Kuner, Springer-Verlag, 117-126, 1991.Schlickewei W, Paul Ch., Initial clinical findings with Bio-Oss. Hefte zur Unfallheikunde, Heft 216, Hrsg. AH Huggler, EH Kuner, Springer-Verlag, 12-137, 1991
Millenium Research Group, US Dental Bone graft Substitutes & Biomaterials (market report). 2003.
Millenium Research Group, The European Market for Dental Bone Graft Substitutes (market report). Implant Dentistry 2003;12:3-5.
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