Scientifically Proven Mechanism of Action

Extensive in-vitro and animal studies have demonstrated that PDGF is a broad acting growth factor with mitogenic (cell proliferation) and chemotactic (cell recruitment) effects on osteoblasts, cementoblasts and periodontal ligament cells. In fact, the PDGF contained in GEM 21S® significantly increases the proliferation and migration of osteoblasts and other cells of the periodontium.^1,2,3

	After implantation, PDGF is released from the β-TCP matrix into the surrounding environment. PDGF then binds to specific cell surface receptors on the target cells initiating a cascade of intracellular signaling pathways.

	PDGF-induced intracellular events lead to directed cell migration or chemotaxis and cell proliferation or mitogenesis of osteoblasts, periodontal ligament fibroblasts and cementoblasts.

	Proliferation of osteoblasts, periodontal ligament fibroblasts and cementoblasts lead to increased matrix synthesis, resulting in formation of new alveolar bone, periodontal ligament and cementum. Angiogenesis (blood vessel formation) continues.

	Clinical data suggests that over time (approximately 6 months), maturation of supporting alveolar bone, cementum and periodontal ligament occurs. The end result is enhanced bone and periodontal regeneration and retention of the natural tooth.

	The goal of using GEM 21S® Growth-factor Enhanced Matrix is to restore normal esthetics, anatomic form and function.

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